The Tasman Highway south of St Helens has been closed after hazardous material spilled across the road and could stay shut until Friday evening.
Firefighters are currently at the scene working to clean up the spill near Basin Creek Road.
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It is understood a truck rolled earlier on Friday morning, with police and emergency services called to the incident around 11am.
The Tasmania Fire Service has issued a hazardous material advice, warning that exposure to the substance may be dangerous.
However, they say there is no risk of exposure to the general public at this time.
Motorists are being asked to avoid the area until the scene is clear, which is expected to occur around 5pm.
