The Tasman Bridge is currently blocked, impacting traffic in both directions, following a multi-vehicle crash.
Emergency services are at the scene of the incident involving at least three vehicles, which is causing significant delays for commuters.
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Traffic is backed up across the city, with the Tasman Highway and Brooker Highway at a standstill.
Macquarie Street through the Hobart CBD is also starting to slow down to a crawl.
Police say motorists should avoid the area until the scene is cleared.