A man has been airlifted to the Royal Hobart Hospital after a truck rolled near Devonport Airport this morning.
Police say the crash happened on Airport Road at Wesley Vale around 11am.
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A 64-year-old man from Sheffield, who was travelling as a passenger, suffered serious injuries.
The driver escaped with only minor injuries.
The road is closed between Mill Road and Wesley Vale Road as emergency crews remain at the scene.
Police say the cause of the crash is still being investigated.