A vehicle has reportedly spun out on the Huon Highway, blocking one lane near Vinces Saddle.
The crash has impacted traffic heading towards Kingston, with delays expected until the scene is cleared.
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Police on the scene say no serious injuries have been reported at this stage.
The incident comes as multiple road weather alerts are in place across Tasmania, warning of icy conditions.
Motorists are being urged to avoid the area or anticipate delays and adjust their travel plans accordingly.
