Davey Street in Hobart is currently blocked following a multi-vehicle crash at the Murray Street intersection.
Emergency services are on the scene and are treating occupants with minor injuries.
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Police say the vehicles involved will need to be towed away, with the left lane on Davey Street completely blocked.
Southbound traffic is backed up past Macquarie Point.
Motorists are advised to approach the area with caution or seek an alternate route.