Main Road in Montrose has been closed following a serious crash earlier this morning.
The incident has shut down the road between Riverview Parade and Marys Hope Road as specialist police resources examine the scene and conduct an investigation.
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A male driver of one of the vehicles involved was taken to the Royal Hobart Hospital for treatment around 7am.
His condition is understood to be serious.
Police are asking motorists to avoid the area and find alternate routes if possible.
