Multiple crashes on the Southern Outlet at Tolmans Hill are blocking southbound lanes and causing delays for Hobart drivers.
Tasmania Police and emergency services responded to the incidents shortly before 6pm on Monday.
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The crashes involved multiple vehicles on the southbound lanes past the Olinda Grove overpass in peak-hour traffic.
Police say no serious injuries have been reported.
Southbound lanes will stay blocked while the scenes are cleared.
Motorists have been told to avoid the area until further notice.
